| ncRNA name | stathmin siRNA |
| ncRNA Category | siRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RB cell line Y79 |
| Methods | siRNA transfection, MTT assay, flow cytometry, transwell assay, qRT-PCR, Western blot, immunohistochemistry staining |
| Expression pattern | associated |
| Functional description | Short interfering RNA-mediated transient stathmin downregulation resulted in a marked inhibition of retinoblastoma cell proliferation and cell invasion in vitro. Stathmin inhibition promoted Y79 cells to G2/M phase. Cells transfected with stathmin siRNA showed long and bundled microtubule polymers and sensitized the Y79 cells significantly to paclitaxel and vincristine. |
| PubMed ID | 21546534 |
| Year | 2011 |
| Title | Reversal of stathmin-mediated microtubule destabilization sensitizes retinoblastoma cells to a low dose of antimicrotubule agents: a novel synergistic therapeutic intervention. |
| Drug-related ncRNA | NO |
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